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Drug Factsheets

Vincristine

(vincristine)

In this factsheet:

DIN (Drug Identification Number)

02143305 VINCRISTINE SULPH 1MG/ML VL


How does Vincristine work? What will it do for me?

Vincristine belongs to the group of cancer-fighting medicines known as antineoplastics. It causes the death of cancer cells by interfering with the genetic material DNA, which is necessary for their growth and reproduction.

Vincristine is used alone or in combination with other antineoplastic medications for the treatment of many different types of cancer, including leukemia (cancer of white blood cells), lymphoma (cancer of the lymph cells), breast cancer, lung cancer, malignant melanoma, cancer of the uterine cervix, colorectal cancer, and Wilms' tumor. Your doctor may choose to use this medication for other conditions not listed here. If you're unsure why you are taking this medication, please ask your doctor.

How should I use Vincristine?

The recommended dose and dosing schedule of vincristine varies according to the specific type of cancer being treated, the response to therapy, and the other drugs or treatments being used. The dose administered is also based on body size.

Vincristine is injected into a vein through a specially prepared site on your skin that has been prepared for this purpose. It is usually scheduled to be given on a weekly basis. Very careful handling of this medication is required. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.

As well as interfering with the genetic material DNA of cancer cells, vincristine can interfere with some of your normal cells. This can cause a number of side effects such as hair loss. Vincristine sometimes causes mild nausea and vomiting, but it is important to keep using this medicine even if you feel ill. Your doctor, nurse or pharmacist can advise you on how to reduce the effects of nausea and vomiting. Your doctor may want you to drink extra fluid while using this medication to prevent kidney problems. Keep track of any side effects and report them to your doctor as suggested in the section "What side effects are possible with this medication?"

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does Vincristine come in?

Each mL contains vincristine sulfate 1 mg. Nonmedicinal ingredients: mannitol 100 mg, methylparaben and propylparaben 0.2 mg as preservatives, and water for injection. Sodium hydroxide and/or sulphuric acid for pH adjustment.

Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

Who should NOT take Vincristine?

Vincristine should not be used by anyone allergic to vincristine or any of the ingredients of the preparation.

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